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AIDEVI Let You Know What does NMN do to your body ? And What is the NMN side effectives ?

Dec 29,2022 | AIDEVI

AIDEVI Let U KnowWhat does NMN do

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AIDEVI NMN has been shown to boost levels of an essential molecule with crucial roles in over 400 metabolic reactions called nicotinamide adenine dinucleotide (NAD+). Falling NAD+ levels with age have been linked to age-related conditions in animals like mice and rats and even humans, but increasing NAD+ with NMN improves these ailments.

Age-related NAD+ level reductions have been linked to a plethora of age-related human diseases, and some studies provide evidence that increasing NAD+ combats these conditions. For example, one study has shown that NMN supplementation increases muscle function in aged men while another indicates that it increases insulin sensitivity in older women.

NMN studies from institutes like Harvard University and Washington University have shown that supplementing with the molecule or enhancing NMN synthesis promotes longevity and health during aging in rodents. Sinclair and colleagues found that when aged mice drank NMN-infused water, their running endurance almost doubled. Further studies have demonstrated that injecting mice with NMN preserves cognition during aging. Moreover, a study from Imai and colleagues indicates that an upsurge in NMN synthesis more than doubles the remaining lifespan of mice.

(Das et al., 2018 | Cell) NMN substantially enhances running endurance in aged mice. Aged mice (20 months old) given 400 mg/kg/day of NMN in drinking water displayed significantly extended running times before they stopped running from exhaustion.(Tarantini et al., 2019 | Redox Biology) NMN provides neuroprotective benefits to preserve cognition in aged mice. The heatmap showing the paths that mice took to escape from a water maze indicates that aged mice made more errors than young mice but that taking NMN ameliorated these mistakes. The graph to the right shows aged mice made significantly more memory errors than young mice in the water maze but that NMN rescued aged mouse memory. These findings support that NMN enhances cognition during aging.(Yoshida et al., 2019 | Cell Metabolism) Injecting mice with an enzyme that drives NMN synthesis more than doubles the remaining lifespan of female mice. Injecting female mice with vesicles containing the NMN synthesis enzyme nicotinamide phosphoribosyltransferase (NAMPT) more than doubles their remaining lifespan (Figure J). The upsurge in NMN synthesis also improves overall fitness as seen by the health of the mice’s fur coat (top mouse injected with vesicles containing NAMPT in Figure K).(Hong et al., 2021 | Frontiers in Cell and Developmental Biology) NMN ameliorates a number of age-related diseases by increasing NAD+ levels. NMN’s health-related benefits extend to tissues ranging from the heart to the eye to the brain.

Taking NMN may provide a promising means to combat age-related diseases and ailments. Below is a summary of major studies elucidating the potential benefits of NMN.

 

Research Category Summary / Conclusion Mouse / Rat Human Pig
Bone Repair
  • Rejuvenates bone marrow stem cells and promotes bone formation.2343536

     
Cancer
  • Enhances tumor suppression effect of immunotherapies.33846

  • Reduces toxic side effects of chemotherapies.3739

     
Cardiovascular
  • Restores heart and blood vessel function.4232540427884

  • Protects heart against damage after heart attack.4143

  • Prevents heart failure by promoting the health of mitochondria.44

     
DNA Repair
  • Enhances DNA repair mechanisms. 18

     
Eye Protection
  • Promotes eye recovery after injury.6318089

  • Improves dry eye by reducing inflammation and increasing oil secretion.1745

     
Immunity
  • Promotes recovery from COVID-19.7

  • Reduces severe allergic reaction.50

  • Reduces inflammation by supressing immune cell activation.51

     
Longevity
  • Doubles lifespan.8

  • Restores cardiovascular, cognitive, and metabolic decline.20

  • Doubles telomere length.552

     
Metabolism
  • Improves insulin sensitivity and glucose metabolism.927484987

  • Enhances energy production by rejuvenating mitochondria.212947

  • Reduces fat circulating in blood.85

     
Neurological
  • Improves cognitive deficits and brain defects in Alzheimer's.105364

  • Improves age-related cognitive impairment and protects against blood vessel and brain damage.5556575961626365

  • Promotes brain function recovery after hemorrhage and stroke.1258

  • Protects against neurodegeneration and cognitive impairments associated with diabetes.60

  • Reduces stroke caused from high salt consumption.33

  • Redcues depressive behavior.11

     
Reproduction
  • Improves fertility and age-related decline in oocyte (egg) qaulity.136683

  • Protects oocytes against environmental toxins.19

     
Skin and Muscle
  • Increases muscle strength and improves exercise endurance.697172

  • Protects against skin aging.707982

     
Organ Health
  • Reduces alcohol-induced liver damage.14

  • Reduces liver scarring.16

  • Protects against kidney damage.15748190

  • Rejuvenates age-related decline of intestines.757686

     
Mechanism
  • A protein that transports NMN into cells has been identified.1

  • Induces metabolic shift in damaged cells to promote survival.77

  • Increases production of nucleotides (DNA building blocks) in mitochondria.88

     

 

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