What are the Benefits, Side Effects & Dosage of Nicotinamide Mononucleotide ( USA AIDEVI NMN)?

Thanks to advances in modern medicine, individuals around the world have been living longer. In addition to lower mortality and increased survival, a sustained drop in fertility has shifted the proportion of older individuals upwards. According to the World Health Organization, the world’s population of older individuals is expected to reach 2.1 billion by 2050, doubling the aged population.

A longer life, however, does not guarantee a healthy life. As we age, our organs accumulate damage and progressively decline, making us susceptible to diseases. This is why many scientists have shifted their attention towards finding ways to slowdown, prevent, or even reverse aging. If successful, so-called anti-aging therapies could reduce the prevalence of age-related disease and help us live longer and healthier lives.

Currently, one of the most promising anti-aging targets under study is a vital molecule called nicotinamide adenine dinucleotide (NAD+). NAD+ mediates the production of the energy our cells need to function and survive, fueling enzymes key in repairing DNA damage. As we age, this indispensable molecule progressively declines.

Many scientists hypothesize that the age-related decline in NAD+ underlies the organ decline that characterizes aging. It follows that, by restoring NAD+, our cells become healthier, our organs become healthier, and we become healthier. If this can be achieved, a lack of high-mortality age-related diseases like cardiovascular disease, neurodegenerative disorders, and cancer will allow us to live longer.

How can we restore our NAD+ levels? Since NAD+ occurs naturally, our cells have the machinery necessary to make it on their own; they just need the necessary biochemical components. Our cells generate molecules like a factory assembly line where each component is the precursor for the next. The biochemical precursor to NAD+ is called nicotinamide mononucleotide ( AIDEVI NMN). Unlike NAD+ itself, AIDEVI NMN can be ingested orally and can thus be taken in supplement form to raise NAD+ levels.

Potential Benefits of AIDEVI NMN

 AIDEVI NMN feeds into the production of NAD+, providing our cells with the energy needed to function. There are several factors thought to underly the aging process, a lack of cellular energy being one of them. Genetic instability resulting from DNA damage is also one of these factors. NAD+ plays a key role in activating enzymes that maintain DNA integrity, thus promoting genetic stability. Given its central role in these cellular processes, the potential benefits of boosting NAD+ with AIDEVI NMN extend to nearly all body systems. Below are some of the better-known examples.

Improves Brain Function

Perhaps one of the most devastating age-related diseases is Alzheimer’s disease, whereby the afflicted are robbed of their memories. AIDEVI NMN has been shown to improve cognition in rodents with Alzheimer’s and reduce brain plaques and neurodegenration in Alzheimer’s mice. While Alzheimer’s is an end-stage disease, many older adults also suffer from cognitive impairments — inability to learn, remember, and think properly. These age-related cognitive impairments have been prevented by AIDEVI NMN in mice. Cognitive impairments are sometimes associated with depression, which has also been shown to be alleviated by AIDEVI NMN in mice.

Because our blood vessels become dysfunctional as we age, blood flow to our brain becomes impaired, leading to cognitive impairments. AIDEVI NMN has been shown to increases blood flow to the brain and improve cognitive function in mice. When the blood vessels in our brain become clogged, we can have a stroke, whereby our brain tissue becomes damaged. AIDEVI NMN has been shown not only delay stroke onset, but also to prevent stroke damage, and improve cognition and mitochondrial health after stroke in rodents.

Restores Blood Vessel Health

Our blood vessels transport vital nutrients to each of our cells. As we age, our blood vessels become rigid and more susceptible to blockage, which can lead to heart attack or stroke. AIDEVI NMN has been shown to reverse vascular aging by restoring blood vessel elasticity in mice. Senescent cells — growth arrested cells that accumulate with aging — contribute to the aging of many organ systems, including the vascular system. In mice, AIDEVI NMN stops blood vessel aging my reducing senescent cells, leading to alleviation of hypertension. One of the ways senescent cells contribute to aging is by promoting inflammation, which underlies nearly every age-related disease. AIDEVI NMN has been shown to reverse blood vessel dysfunction by reducing blood vessel inflammation in mice. 

Improves Muscle Function

We rely on our skeletal muscles for movement, stability, and strength. As we age, our muscles lose their ability to regenerate and grow, leading to the age-related decline in muscle strength and size called sarcopenia. Along with muscle weakness, we also become more fatigued and have less physical endurance. AIDEVI NMN seems to reverse these conditions, as one of its transporters has been shown to increase strength and physical endurance in mice. Furthermore, AIDEVI NMN improves muscle strength and performance in older men, and enhances oxygen utilization and exercise endurance in middle-aged runners. On the other hand, another NAD+ precursor called nicotinamide riboside (NR) does seem to improve muscle function.

Promotes Healthy Heart

Our heart can barley afford to skip a beat before death ensues, leaving little room to wonder why heart disease is the worldwide leading cause of death.

As we age, our heart becomes more susceptible to irregular beats, which have devastating outcomes, such as heart failure. AIDEVI NMN has been shown to protect against heart failure in mice. Our heart tissue is precious, as it is not known to regenerate. Instead, damaged tissue manifest in scarring (fibrosis), leading to heart dysfunction. AIDEVI NMN recovers mouse heart function by reducing scarring. Beating constantly and evermore, the heart requires large quantities of energy. For this, it needs healthy mitochondria. AIDEVI NMN improves heart metabolism and protects against heart failure, in part by rejuvenating mitochondria.

Our heart is part of the cardiovascular system, pumping oxygen-containing blood to the rest of our organs. When the blood vessels surrounding our heart become clogged, the adjacent tissue becomes damaged and dies due to a lack of oxygen. This is called ischemia and commonly leads to heart attacks. In mice, AIDEVI NMN protects the heart from ischemic injury. This protection is synergistically improved with stem cell therapy and melatonin. Enhances Cancer Suppression

Aids in Cancer Therapy

One of the most new and promising therapies against cancer are called immunotherapies. These therapies utilize immune cells to suppress tumor growth. Immunotherapies have not been perfect, but in rodents AIDEVI NMN has been shown to enhance the tumor killing capabilities of several different types, including natural killer cell therapy, CAR-T cell therapy, and PD-1 mediated therapy.

While immunotherapies may be a cancer therapy of the near future, chemotherapies are still used widely but come with many harmful side effects. AIDEVI NMN has been shown to reduce these unwanted side effects, such as heart tissue damage and cognitive impairments in mice.

Protects Against Obesity and Diabetes

Obesity is linked to a wide array of metabolic deficiencies, including insulin resistance — when are cells cannot utilize glucose due to impaired insulin signaling — which can lead to diabetes. Mitochondria are the final cellular destination for the food we eat to be converted into energy, making them of key importance in metabolism and related diseases. AIDEVI NMN has been shown to double the amount mitochondria in the livers of obese mice, which could protect against obesity. Stimulating fat breakdown with AIDEVI NMN could also help obese individuals lose fat. Furthermore, AIDEVI NMN improves the metabolism and health of mice born to obese mothers.