FDA Lifts Ban on NMN: Turning Point for the 'Longevity Vitamin' Market
A regulatory tug-of-war over anti-aging supplements has finally come to an end, as the scientific and industrial communities redefine the possibilities of healthy human aging.
On September 29 (U.S. time), the Natural Products Association (NPA) announced on its official website that the U.S. Food and Drug Administration (FDA) has officially reversed its stance and confirmed the legality of β-Nicotinamide Mononucleotide (#NMN) in dietary supplements.
“Today’s FDA decision confirms that NMN is legal for use in supplements. We now urge e-commerce platforms to immediately restore NMN products to the market,” said Dr. Daniel Fabricant, President and CEO of the NPA.
This decision ends nearly three years of regulatory uncertainty, providing clear direction for the multi-billion-dollar anti-aging supplement industry.
What is NMN?
Nicotinamide Mononucleotide (NMN) is a derivative of vitamin B3 and a direct precursor of Nicotinamide Adenine Dinucleotide (NAD+), a vital coenzyme within cells. Structurally, NMN consists of a nicotinamide group and a ribonucleotide connected via a phosphate bond, allowing it to directly participate in NAD+ biosynthesis.
NAD+ is the central coenzyme of cellular energy metabolism, involved in thousands of biochemical reactions in the human body, often referred to as the “powerhouse” of the cell. Of particular importance are the sirtuin proteins, which play crucial regulatory roles in metabolism, inflammation, and DNA repair.
However, scientific research has shown that NAD+ levels decline significantly with age. Studies indicate that by age 40, NAD+ levels drop to about 50% of youthful levels, a trend strongly associated with age-related diseases.
Because NAD+ molecules are too large to be directly absorbed, supplementing with its precursor NMN is considered an effective way to boost intracellular NAD+ levels. The body recycles NAD+ through the “salvage pathway,” which interconverts NAM, NMN, and NAD+.
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Core Benefits and Potential Applications of NMN
1. Anti-Aging and Lifespan Extension**
NMN’s most notable benefit lies in its potential to slow or even reverse age-related decline. A study from Harvard Medical School published in *Cell Reports* showed that administering NMN to 22-month-old mice (equivalent to 60-year-old humans) for one week restored mitochondrial stability and muscle health to levels similar to 6-month-old mice (equivalent to 20-year-old humans).
Human trials also found that 8 weeks of NMN supplementation reduced fatigue and improved multiple metabolic health markers.
2. Metabolic Regulation and Insulin Sensitivity**
A 2021 *Science* study by Washington University School of Medicine found that oral NMN supplementation enhanced insulin sensitivity. Another clinical trial involving healthy men aged 50–70 showed that taking 250 mg of NMN daily for six weeks significantly improved insulin sensitivity without adverse effects.
3. Neuroprotection and Cognitive Function**
Studies from Nanjing Medical University and Tongji University revealed that NMN supplementation significantly improved cognitive impairment, neuroinflammation, and β-amyloid deposition in Alzheimer’s disease mice. The mechanism likely involves SIRT1 activation, enhanced DNA repair, and improved mitochondrial function.
4. Reproductive System Protection**
A 2025 study published in *Reproductive Biology* found that NMN protected against soybean isoflavone-induced testicular damage in mice, improving reproductive parameters by regulating autophagy and proliferation-related genes.
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The Regulatory Battle
The U.S. NMN controversy began in November 2022 when the FDA determined that NMN could not be marketed as a dietary supplement under the Federal Food, Drug, and Cosmetic Act’s drug exclusion clause. This decision sparked backlash from the supplement industry, leading to a citizen petition urging FDA to reverse its decision or exercise enforcement discretion.
The NPA later sued the FDA, arguing that its retroactive enforcement was illegal. Following administrative turmoil and mass layoffs in April 2025, the FDA postponed its NMN ruling to September 30. During the interim, the FDA maintained a “non-prioritized enforcement” policy, allowing NMN supplements to remain on the market.
Globally, regulatory attitudes toward NMN vary:
- **Japan**: The first country to approve NMN human trials and legalize NMN as a food ingredient.
- **Europe**: NMN is not approved as a food or supplement ingredient; manufacturing or selling NMN products is illegal.
- **Australia**: NMN is not approved for domestic sale but may be exported.
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Rational Perspectives on NMN
Despite NMN’s promise, consumers should remain cautious. Current research faces three key limitations:
1. Lack of age-specific dosage clinical data.
2. Unclear long-term metabolic impacts.
3. Bioequivalence differences across manufacturing methods.
Future progress will rely on organoid models and AI-driven prediction for precision interventions. Consumers should choose NMN products with verified certifications, scientific backing, and legitimate sales channels to ensure safety and efficacy.
AIDEVI NMN 18000: Scientifically Proven, Market-Tested, and Trusted by Thousands
Over the past three years, AIDEVI #NMN18000 has achieved remarkable success in the U.S. dietary supplement market, with sales exceeding tens of thousands of bottles and earning recognition as one of the most trusted NMN products for cellular health and anti-aging. In a landscape where consumers demand both safety and efficacy, AIDEVI stands out through a commitment to scientific integrity, verified results, and exceptional value.
Each capsule of AIDEVI NMN 18000 contains 99.9% pharmaceutical-grade β-nicotinamide mononucleotide (NMN), formulated for maximum absorption and bioavailability. The product supports NAD+ restoration, enhancing mitochondrial energy production, DNA repair, and metabolic balance—key processes that naturally decline with age. This formula was developed in cooperation with leading nutritional scientists and manufactured under GMP and FDA-compliant facilities, ensuring purity, safety, and consistency in every batch.
What truly sets AIDEVI apart is its evidence-based efficacy and high cost-performance ratio. Consumers report tangible improvements in energy levels, focus, sleep quality, and overall vitality within weeks of use. Such positive feedback reflects AIDEVI’s mission—to make high-quality NMN supplementation accessible without compromising scientific credibility or safety.
As the FDA officially recognizes NMN as a legal dietary supplement, the market enters a new phase of growth and standardization. In this evolution, #AIDEVI NMN 18000 remains a benchmark for quality and transparency. Every bottle represents more than a supplement—it embodies a scientific approach to longevity, empowering individuals to take control of their cellular health.
For thousands of customers who have experienced real, visible results, AIDEVI is not just another NMN brand; it’s a trusted partner in the pursuit of healthy aging and optimized life performance.
Conclusion
With regulatory barriers removed, the NMN market is expected to experience renewed growth. As global aging accelerates, demand for longevity and wellness will continue to rise. Ongoing scientific research may soon yield optimized NMN dosing for different age groups and health profiles.
NMN is no longer just an anti-aging supplement—it represents a new molecular biology-based approach to health management.
Reference：
NMN抗衰老保健品2025行情调研白皮书。（2025， April 19）
QYResearch. (2025). 2025年全球及中国烟酰胺单核苷酸（NMN）市场供需情况和“十五五”发展预测
Research and Markets. (2025, July 28). ，U.S. anti-aging supplements (collagen, resveratrol, NMN, vitamins) market trends analysis report 2025-2030，. GlobeNewswire.
Lee, S., Kim, A., Park, J., & Harvard, J. A. (2025). Research progress on anti-aging with natural products: From pathway modulation to AI-driven discovery. Biomolecules, 15(10), 1384.
Treebak, J., ... (2025). NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging. Cell Metabolism.
Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science
Wang, K. (2025). Protective effect of nicotinamide mononucleotide against soybean isoflavone induced damage in mouse testis. Reproductive Biology.
